Corso di Laurea in Viticoltura ed enologia - VE

Prodotti della ricerca selezionati

Arnodo, Davide, Ghinato, Simone, Nejrotti, Stefano, Blangetti, Marco, Prandi, Cristina (2020)
Lateral lithiation in deep eutectic solvents: regioselective functionalization of substituted toluene derivatives.
https://iris.unito.it/handle/2318/1732454

Ghinato S , Dilauro G , Perna F M , Capriati V , Blangetti M , Prandi C (2019)
Directed: Ortho-metalation-nucleophilic acyl substitution strategies in deep eutectic solvents: The organolithium base dictates the chemoselectivity.
https://iris.unito.it/handle/2318/1707022

Lazzarato L , Gazzano E , Blangetti M , Fraix A , Sodano F , Picone G M , Fruttero R , Gasco A , Riganti C , Sortino S (2019)
Combination of PDT and NOPDT with a tailored BODIPY derivative.
https://iris.unito.it/handle/2318/1718827

Prandi, Cristina, Nejrotti, Stefano, Iannicelli, Marta, Jamil, Salwa Simona, Arnodo, Davide, Blangetti, Marco (2019)
Natural Deep Eutectic Solvents as an Efficient and Reusable Catalytic System for the Nazarov Cyclization.
https://iris.unito.it/handle/2318/1717748

Prandi, Cristina, Blangetti, Marco, Namdar, Dvora, Koltai, Hinanit* (2018)
Structure-activity relationship of cannabis derived compounds for the treatment of neuronal activity-related diseases.
https://iris.unito.it/handle/2318/1685154

Bellomo, Chiara, Chaari, Mahdi, Cabrera-González, Justo, Blangetti, Marco, Lombardi, Chiara, Deagostino, Annamaria, Viñas, Clara, Gaztelumendi, Nerea, Nogués, Carme, Nuñez, Rosario*, Prandi, Cristina (2018)
Carborane-BODIPY Dyads: New Photoluminescent Materials through an Efficient Heck Coupling.
https://iris.unito.it/handle/2318/1685153

Sodano, Federica, Gazzano, Elena, Fraix, Aurore, Rolando, Barbara, Lazzarato, Loretta, Russo, Marina, Blangetti, Marco, Riganti, Chiara, Fruttero, Roberta, Gasco, Alberto, Sortino, Salvatore (2018)
A Molecular Hybrid for Mitochondria-Targeted NO Photodelivery.
https://iris.unito.it/handle/2318/1656033

Argenziano M , Lombardi C , Ferrara B , Trotta F , Caldera F , Blangetti M , Koltai H , Kapulnik Y , Yarden R , Gigliotti L , Dianzani U , Dianzani C , Prandi C , Cavalli R (2018)
Glutathione/pH-responsive nanosponges enhance strigolactone delivery to prostate cancer cells.
https://iris.unito.it/handle/2318/1683582

Blangetti, Marco, Rolando, Barbara, Marini, Elisabetta, Chegaev, Konstantin, Guglielmo, Stefano, Lazzarato, Loretta, Laura, Lucarini, Emanuela, Masini, Fruttero, Roberta (2017)
gem-Dinitroalkyl Benzenes: A Novel Class of IOP-Lowering Agents for the Treatment of Ocular Hypertension.
https://iris.unito.it/handle/2318/1650704

Blangetti, Marco, Rolando, Barbara, Chegaev, Konstantin, Guglielmo, Stefano, Lazzarato, Loretta, Durante, Mariaconcetta, Masini, Emanuela, Almirante, Nicoletta, Bastia, Elena, Impagnatiello, Francesco, Fruttero, Roberta, Gasco, Alberto (2017)
New furoxan derivatives for the treatment of ocular hypertension.
https://iris.unito.it/handle/2318/1625289

Chegaev, Konstantin, Fraix, Aurore, Gazzano, Elena, Abd Ellatef, Gamal Eldein F , Blangetti, Marco, Rolando, Barbara, Conoci, Sabrina, Riganti, Chiara, Fruttero, Roberta, Gasco, Alberto, Sortino, Salvatore (2017)
Light-Regulated NO Release as a Novel Strategy To Overcome Doxorubicin Multidrug Resistance.
https://iris.unito.it/handle/2318/1627517

Blangetti, Marco, Fraix, Aurore, Lazzarato, Loretta, Marini, Elisabetta, Rolando, Barbara, Sodano, Federica, Fruttero, Roberta, Gasco, Alberto, Sortino, Salvatore (2017)
A Nonmetal-Containing Nitric Oxide Donor Activated with Single-Photon Green Light.
https://iris.unito.it/handle/2318/1647038

Fraix, Aurore, Blangetti, Marco, Guglielmo, Stefano, Lazzarato, Loretta, Marino, Nino, Cardile, Venera, Graziano, Adriana C E , Manet, Ilse, Fruttero, Roberta, Gasco, Alberto, Sortino, Salvatore (2016)
Light-Tunable Generation of Singlet Oxygen and Nitric Oxide with a Bichromophoric Molecular Hybrid: a Bimodal Approach to Killing Cancer Cells.
https://iris.unito.it/handle/2318/1567186

Gazzano, Elena, Chegaev, Konstantin, Rolando, Barbara, Blangetti, Marco, Annaratone, Lorenzo, Ghigo, Dario, Fruttero, Roberta, Riganti, Chiara (2016)
Overcoming multidrug resistance by targeting mitochondria with NO-donating doxorubicins.
https://iris.unito.it/handle/2318/1556538

Guglielmo, Stefano, Contino, Marialessandra, Lazzarato, Loretta, Perrone, Maria Grazia, Blangetti, Marco, Fruttero, Roberta, Colabufo, Nicola Antonio (2016)
A Potent and Selective P-gp Modulator for Altering Multidrug Resistance Due to Pump Overexpression.
https://iris.unito.it/handle/2318/1600302

Marco, Blangetti, Roberta, Fruttero, Loretta, Lazzarato, Barbara, Rolando, Marta, Giorgis, Alberto, Gasco, Nicoletta, Almirante, Laura, Storoni (2015)
Quinone based nitric oxide donating compounds.
https://iris.unito.it/handle/2318/1530732

Das, Manas, Manvar, Atul, Jacolot, Maiwenn, Blangetti, Marco, Jones, Roderick C , O', Shea, Donal F (2015)
Stereoselective peterson olefinations from bench-stable reagents and N-phenyl imines.
https://iris.unito.it/handle/2318/1657854

Prandi Cristina, Ghigo Giovanni, Occhiato Ernesto Giovanni, Scarpi Dina, Begliomini Stefano, Lace, Beatrice, Alberto Gabriele, Artuso Emma, Blangetti Marco (2014)
Tailoring fluorescent strigolactones for in vivo investigations: a computational and experimental study.
https://iris.unito.it/handle/2318/144062

Konstantin Chegaev, Loretta Lazzarato, Yasinalli Tamboli, Donatella Boschi, Marco Blangetti, Andrea Scozzafava, Fabrizio Carta, Emanuela Masini, Roberta Fruttero, Claudiu T Supuran, Alberto Gasco (2014)
Furazan and furoxan sulfonamides are strong α-carbonic anhydrase inhibitors and potential antiglaucoma agents.
https://iris.unito.it/handle/2318/147999

Marco Blangetti, Helena Rosso, Cristina Prandi, Annamaria Deagostino, Paolo Venturello (2013)
Suzuki-Miyaura Cross-Coupling in Acylation Reactions, Scope and Recent Developments.
https://iris.unito.it/handle/2318/127085

Cristina Prandi, Helena Rosso, Beatrice Lace, Ernesto G Occhiato, Alberto Oppedisano, Silvia Tabasso, Gabriele Alberto, Marco Blangetti (2013)
Strigolactone analogs as molecular probes in chasing the (SLs) receptor/s: design and synthesis of fluorescent labeled molecules.
https://iris.unito.it/handle/2318/127842

Blangetti, Marco, Muller-Bunz, Helge, O', Shea, Donal F (2013)
Synthesis, separation, and structural analysis of planar chiral carboxy-substituted [2.2]metacyclophanes.
https://iris.unito.it/handle/2318/1657790

Blangetti, Marco, Muller-Bunz, Helge, O', Shea, Donal F (2013)
First asymmetric synthesis of planar chiral [2.2]metacyclophanes.
https://iris.unito.it/handle/2318/1657542

Blangetti, Marco, Muller-Bunz, Helge, O', Shea, Donal F (2012)
Homo- and Hetero-oxidative Coupling of Benzyl Anions.
https://iris.unito.it/handle/2318/1507538

Blangetti, Marco, Fleming, Patricia, O', Shea, Donal F (2011)
Use of mixed Li/K metal TMP amide (LiNK chemistry) for the synthesis of [2.2]metacyclophanes.
https://iris.unito.it/handle/2318/1507537

Marco Blangetti, Annamaria Deagostino, Giuliana Gervasio, Domenica Marabello, Cristina Prandi, Paolo Venturello (2011)
Superbase promoted synthesis of dienamides as useful intermediates for the synthesis of a-ketoamides, g-lactams and cyclic imino ethers.
https://iris.unito.it/handle/2318/88140

Marco Blangetti, Gianluca Croce, Annamaria Deagostino, Eleonora Mussano, Cristina Prandi, Paolo Venturello (2011)
Asymmetric Synthesis of Ethoxydienamines in Superbasic MediumMediated by Chiral Sulfinyl Group.
https://iris.unito.it/handle/2318/83844

Marco Blangetti, Annamaria Deagostino, Cristina Prandi, Silvia Tabasso, Paolo Venturello (2009)
LIC-KOR-Promoted Synthesis of Alkoxydienyl Amines: An Entry to 2,3,4,5-Tetrasubstituted Pyrroles.
https://iris.unito.it/handle/2318/61988

Marco Blangetti, Annamaria Deagostino, Cristina Prandi, Chiara Zavattaro, Paolo Venturello (2008)
N-Metalated imines by reaction of 1,1-diethoxybut-2-ene with aromatic nitriles, as useful intermediates for the synthesis of substituted pyrimidines and cyclopentenones.
https://iris.unito.it/handle/2318/105036

Marco Blangetti, Annamaria Deagostino, Helèna Rosso, Cristina Prandi, Chiara Zavattaro, Paolo Venturello (2007)
Rapid and Easy Access to (E)-1,3-Enynes, 1,3-Diynes and Allenes Starting from Propargylic Acetals, Exploiting the Different Reactivity of Lithium and Mixed Lithium-Potassium Organometallic Reagents.
https://iris.unito.it/handle/2318/26755

Insegnamenti

• Aspetti avanzati in chimica organica con laboratorio (CHI0212)
  Corso di laurea in Chimica per la manifattura sostenibile
• CHIMICA ORGANICA I - Corso A (cognomi A-K) (MFN1164)
  Corso di laurea in Chimica e Tecnologie Chimiche
• IDENTIFICAZIONE DI COMPOSTI ORGANICI (CHI0085)
  Corso di laurea magistrale in Chimica
• LABORATORIO DI SINTESI ORGANICHE (CHI0124)
  Corso di laurea in Chimica e Tecnologie Chimiche

Temi di ricerca

Project 20228W9TBL (PRIN2022) - Unlocking Greener Metal-assisted Synthetic Tactics by Sustainable Solvents and Technologies (SUSMET)

Period: 16/10/2023-28/02/2026

Role: Principal investigator (PI)

Funding: Unione Europea–Next Generation EU, Missione 4 Componente 1 (CUP: D53D23010260006). Eur 218000 

Academic partners

Operational Unit 1: UNITO. Associated Investigator: Marco Blangetti – Associate Professor (L. 240/10) Università degli Studi di Torino, Department of Chemistry (Via P. Giuria 7, Torino)

Operational Unit 2: UNIMI. Associated Investigator: Laura Castoldi – Associate Professor (L. 240/10). Università degli Studi di Milano, Department of Pharmaceutical Sciences (Via Golgi, 19 - Corpo A, Milano)

Operational Unit 3: UNIBA. Associated Investigator: Leonardo Degennaro – Associate Professor (L. 240/10). Università degli Studi di Bari “Aldo Moro”, Department of Department of Pharmacy-Drug Sciences (Via E. Orabona 4, Bari)

Aim of the project

The increasing awareness of the harmful impact of chemical manufacturing processes, in particular of fine chemicals and pharmaceutical productions, has pressured companies to become more proactive in the development of new sustainable technologies. The implementation of sustainable solvents, mild and eco-friendly reaction conditions and synthetic approaches, and enabling technologies into new efficient protocols for the production of target molecules represents nowadays the main challenge of industrial research. In this context, the design of telescoped chemo- and stereoselective synthetic tactics under bench-type conditions, combined with flow or mechanochemical technologies, remains hitherto under-unexplored and constituted the core of the proposal.

With the aim to satisfy the increasing demand for the introduction of sustainable tactics in synthesis, the main target of the proposal was focused on the upgrade of the traditional chemistry of short-lived and highly reactive carbon-metal species to the use of green, safe solvents and of alternative reaction media, in combination with enabling technologies, in the context of environmental sustainability principles. The scientific goal of SUSMET was to create novel and highly competitive synthetic methods towards a variety of new relevant molecular architectures with controlled chemo-, regio- and stereoselectivity resorting to a) the development of telescoped processes by means of alkali-metal-mediated transformations, b) the introduction of (poly)halogenated metal carbenoids as nucleophilic synthons in sustainable tandem synthetic sequences and c) the design of combined synthetic tactics merging metal-assisted methodologies in unconventional solvents with enabling technologies. In this sense, unprecedented anionic rearrangements under aerobic conditions, novel and/or multiple homologations sequences involving either highly reactive s-block organometallics or metal carbenoids have been developed in a more sustainable perspective by using biomass-derived solvents and simple reaction conditions in combination with enabling green technologies. Finely modulated selectivity of the proposed transformations has expanded the versatility scenario of the project, and important aspects have been deducted by ab initio techniques. Significant opportunities in terms of sustainability will also arise exploiting mechanochemical technologies, as the use of milling reactors can drastically reduce the footprints, the energy consumption, manpower, the risks and environmental impacts of chemical productions, opening the door to greener and safer divergent synthetic routes.

Results obtained

The aim of the SUSMET project was the development of innovative and sustainable synthetic methodologies grounded on the use of organometallic-mediated transformations for the assembly of structurally complex molecular scaffolds, with potential applications in industrial and pharmaceutical fields. The main target of the proposal was focused on the upgrade of the traditional chemistry of short-lived and highly reactive carbon-metal species to the use of green, safe solvents and of alternative reaction media, even by using flow and mechanochemical technologies, in the context of environmental sustainability principles. The specific objectives of the project were:

• The development of telescoped processes for the construction of libraries of new compounds by means of alkali-metal-mediated transformations

The scientific objective was the implementation of sustainable strategies resorting to telescoped synthetic tactics and the development of highly atom-economy processes, such as alkali-metal-promoted anionic cascade rearrangements, for the preparation of highly interesting and unknown molecular scaffolds. This objective was achieved through the development of set of telescoped and/or cascade synthetic protocols grounded on anionic rearrangement reactions and on the controlled use of highly reactive s-block organometallic reagents.

The development of general and efficient anionic carbamoyl-, ester- and silicon-based anionic rearrangement protocols under sustainable conditions, together with the development of base-promoted cascade processes using (poly)halogenated metal carbenoids, allowed a significant increase in the structural complexity of simple molecular skeletons, also using both green solvents and eco-friendly techniques to optimize the classical chemical regime. Furthermore, a protocol which exploits the presence of molecular oxygen, a commonly detrimental species in the chemistry of polar s-block organometallic reagents, was developed. This methodology allows to build poly-substituted scaffolds of remarkable synthetic value in a single synthetic operation by resorting to a one-pot, tandem sequence of C–C and C–O bond formation events occurring at the same carbon atom, working under air and at room temperature, using the biobased 2-MeTHF as solvent.

Overall, the synthetic methodologies developed within the SUSMET project enabled the preparation of a variety of diverse molecular structures in a chemodivergent and chemoselective fashion by changing the nature of either the organometallic reagents and/or the solvent, thus enlarging the portfolio of alkali-metal-mediated transformations under non-conventional conditions.

• The introduction of (poly)halogenated metal carbenoids as nucleophilic synthons for the development of alternative approaches to diversity-oriented syntheses of relevant molecular architectures.

In the course of the project development, chemoselective synthetic methodologies based on the controlled use of highly reactive carbon-centred organometallic intermediates, with particular emphasis on organometallic carbenoids and related nucleophilic species, have been investigated. The overall scientific objective was to transform the intrinsic high reactivity of these intermediates into a selective synthetic advantage, enabling the preparation of structurally valuable compounds from different classes of electrophilic substrates. This objective was substantially achieved through the development of a coherent set of chemoselective synthetic transformations based on the controlled use of highly reactive carbon-centred intermediates. The experimental results progressively identified a particularly productive range of electrophilic partners, including esters, carbonyl compounds, isocyanates, carbodiimides, and electron-poor heterocycles. This evolution allowed a more focused and fruitful implementation of the research plan, while preserving the central emphasis on homologative and carbenoid-based reactivity. This objective was also accomplished through the development of a sustainable and versatile synthetic platform for the valorisation of halodifluoromethyl-containing building blocks. The results obtained demonstrate the successful implementation of a deconstructive functionalization strategy, moving beyond traditional homologation approaches. The expansion of molecular diversity was also achieved through the synthesis of structurally complex scaffolds exploiting the reactivity of halodifluoromethyl intermediates toward nitrogen nucleophiles, allowing access to relevant heterocyclic frameworks such as piperazin-2-ones and dihydroquinoxalin-2-ones. An important outcome of the reported studies is the preparation of fluorinated scaffolds, which are highly valuable because fluorine can strongly influence molecular properties such as polarity, conformation, and metabolic stability without introducing major steric changes. In this respect, the synthesis of α-fluoromethyl amides, fluorohaloethyl derivatives, and fluorinated heterocycles not only expands the methodological scope of the project but also provides access to structurally relevant building blocks of clear interest for future applications in bioactive-molecule design.

Taken together, these activities define a coherent research path centred on chemoselective reaction design, mechanistic control, and the extension of developed methodologies to structurally complex and potentially bioactive molecular frameworks. Overall, the publications produced during the project development define a coherent and productive research line at the interface of homologation chemistry, chemoselective carbon–carbon bond formation, and increasingly efficient synthetic methodology.

• The design and development of new general and combined synthetic tactics resorting to sustainable technologies.

A central objective of the project was the integration of sustainable practices and enabling technologies, as promoted by SUSMET. In this regard, significant progress was made through the use of greener solvents as alternatives to conventional media the minimization of solvent use where possible and, most importantly, the successful implementation of mechanochemical protocols.

In this regard, significant progresses were made through the replacement of the toxic volatile organic compounds (VOCs) with alternative reaction media where possible with a focus on biodegradable, recyclable, safe and low-cost alternatives, such as 2-methyltetrahydrofuran (2-MeTHF), cyclopentyl methyl ether (CPME), 4-methyltetrahydropyran (4-MeTHP) and DESs (Deep Eutectic Solvents) in alkali-metal-mediated transformations. Furthermore, the implementation of aerobic/protic conditions, which overcomes the traditional limitations associated to the handling of highly reactive s-block organometallic reagents (low temperatures, strictly controlled inert conditions), has been investigated and successfully implemented where possible. The presence of molecular oxygen arising from the use of bench-type aerobic conditions has also been exploited to build poly- substituted scaffolds of remarkable synthetic value in a single synthetic operation.

Additionally, the minimization of solvent use and, most importantly, the successful implementation of mechanochemical protocols further contributed to the achievement of this objective. The adoption of mechanochemistry enabled solvent-free or liquid-assisted transformations, resulting in improved yields, enhanced regioselectivity, and increased reproducibility compared to batch conditions. In particular, mechanochemical activation allowed selective access to α-aminoamide products and heterocyclic derivatives, demonstrating a strong impact on both efficiency and selectivity. These results represent a clear advancement in terms of process intensification and environmental sustainability.

Additional outcomes include a detailed mechanistic understanding of the reaction pathways, supported by computational studies, which provided insights into the role of reaction medium and intermediate stability. This contributes to the rational design of future transformations and strengthens the scientific foundation of the methodologies. An additional relevant outcome is the alignment of the developed methodologies with important principles of sustainable synthesis. In addition to all the benefits described above resulting from the use of more sustainable solvents and technologies, the reported transformations are characterized by high chemoselectivity, good step economy, and reduced need for unnecessary functional-group manipulations or protecting-group strategies. In some cases, they also provide safer or more direct alternatives to less selective or more hazardous synthetic approaches.

Publications:

1. Gnavi, R.; De Nardi, F.; Meazzo, C.; Ghinato, S.; Grimaldi, E.; Maranzana, A.; Prandi, C.; Blangetti, M. “Solvent-controlled, chemodivergent oxidative anionic Fries rearrangement of O-aryl carbamates under aerobic conditions” Sci. 2026, 17, 5701–5711.
2. Castiglione, D.; Nardi, A.; Miele, M.; Castoldi, L.; Pace, V. Chemoselective synthesis of a-fluoromethylamides via the controlled addition of LiCH₂ to N-aryl and N-alkyl isocyanates Commun. 2026, 62, 6155-6159.
3. Castiglione, D.; Amata, S.; Lauria, F.; Maranzana, A.; Baldino, S.; Prado-Roller, A.; Castoldi, L.; Palumbo Piccionello, A.; Pace, V.; Comas Iwasita, E. I. One-pot dearomatizative telescoped addition of C-nucleophiles to fluorinated 1,2,4-oxadiazoles followed by regioselective N-functionalization. Chem. Front. 2026 doi: 10.1039/d5qo01707f.
4. Marra, F.; Morelli, F.; De Nardi, F.; Priola, E.; Coldham, I.; Blangetti, M. “O-Aryl carbamates of 2-substituted piperidines: anionic Fries rearrangement and kinetic resolution by lithiation”. Biomol. Chem. 2025, 23, 8029–8038.
5. De Santis, G.; Maranzana, A.; Lauria, F.; Spennacchio, M.; Andresini, M.; Purgatorio, R.; Colella, M.; Luisi, R.; Degennaro, L. “Tunable Preparation of α‐Aminoacyl Fluorides and α‐Fluoroamides via Base‐Induced Cascade Multiple‐Cleavage Processes from Bromodifluorohydrin Reagents and Amines” Synth. Catal. 2025, 367, e70083.
6. Castiglione, D.; Nardi, A.; Miele, M.; Castoldi, L.; Pace, V. Sequential Ester Homologation–Nucleophile-Guided Functionalization: A Chemoselective Access to Thioesters, Amides, and Acids. Chemistry Methods 2025, 5, e202500067.
7. Castiglione, D.; Miele, M.; Nardi, A.; Castoldi, L.; Pace, V. Chemoselective Synthesis of α-Chloro and α,α-Dichloro acetamidines via the Carbenoids Addition to Inherently Low Electrophilic Carbodiimides. Synth. Catal. 2025, 367, e70001.
8. Miele, M.; Castiglione, D.; Holzer, W.; Castoldi, L.; Pace, V. Chemoselective Homologative Preparation of Trisubstituted Alkenyl Halides from Carbonyls and Carbenoids. Commun. 2025, 61, 1180-1183.
9. Miele, M.; Castiglione, D.; Roller, A.; Castoldi, L.; Pace, V. Geminal Homologative Fluorination of Carbonyl Derivatives en route to 1-Fluoro-2-Haloethyl Skeletons. Commun. 2025, 61, 10792-10795.
10. Castiglione, D.; Fontana, F.; Castoldi, L.; Pace, V. Structural Modifications at the C3 and C30 Positions of the Lupane Skeleton with Carbon-Centred Nucleophiles. Molecules 2025, 30, 3064.
11. Marra, F.; De Nardi, F.; Rossi, F.; Priola, E.; Prandi, C.; Blangetti, M. “4-Methyltetrahydropyran: A Versatile Alternative Solvent for the Preparation of Chiral BINOL Catalysts and the Asymmetric Alkylation of Aldehydes”. J. Org. Chem. 2024, 27, e202400313.
12. De Nardi, F.; Gorreta, G.; Meazzo, C.; Parisotto, S.; Blangetti, M.; Prandi, C. “Wittig Reaction in Deep Eutectic Solvents: Expanding the DES Toolbox in Synthesis”. Eur. J. 2024, 30, e202402090

Dissemination:

The results obtained during the development of the SUSMET project were also presented as oral (OC) and poster (PC) communications at the following national and international conferences and workshops:

1. Castoldi, L. “Heterocumulenes as Versatile Electrophiles for Chemoselective Homologations”, 6^th Anatolian Conference on Organic Chemistry (ACOC6), Belek (Turkey), 11 February 2026. (OC, invited lecture)
2. Marra, F.; Morelli, F.; De Nardi, F.; Coldham, I.; Blangetti, M. “O-Aryl Carbamates of 2-Substituted Piperidines: Anionic Fries Rearrangement and Kinetic Resolution by Lithiation” Japanese-Italian Symposium on Organic Chemistry (JISOC), 12-15 October 2025, Bari (Italy). (OC)
3. Gnavi, R.; Intartaglia, V.; Prandi, C.; Blangetti, M. “The anionic Fries rearrangement of O-aryl carbonates”, XLII Convegno Nazionale della Divisione di Chimica Organica (CDCO 2025), 21–25 September 2025, Villasimius (Italy). (PC)
4. Maranzana, A.; De Santis, G.; Lauria, F.; Spennacchio, M.; Andresini, M.; Purgatorio, R.; Colella, M.; Luisi, R.; Degennaro, L. “Tunable Preparation of α-Aminoacyl Fluorides and α-Fluoroamides via Base-Induced Cascade Multiple-Cleavage Processes from Bromodifluorohydrin Reagents and Amines”, 20th European Symposium on Organic Reactivity, 9–12 September 2025, Padova (Italy). (PC).
5. Castoldi, L. Heterocumulenes as Versatile Electrophiles for Chemoselective Homologations”, 22^nd International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS XXII), 1-5 September 2025, Kyoto (Japan). (PC)
6. Blangetti, M.; Gnavi, R.; De Nardi, F.; Meazzo, C.; Grimaldi, E.; Maranzana, A.; Prandi, C. “Oxidative Anionic homo-Fries Rearrangement Under Bench-Type Aerobic Conditions”, CINMPIS DAYS 2025, 17–18 February 2025, Napoli (Italy). (OC)
7. Degennaro, L. “Use of sustainable technologies enabling direct fluoroalkylation and fluorocarbonylation strategies”, CINMPIS DAYS 2025, 17–18 February 2025, Napoli (Italy). (OC, keynote lecture)
8. De Santis, G.; Nardelli, A.; Maranzana, A.; Colella, M.; Luisi, R.; Degennaro, L. “Mechanochemical Synthesis of Piperazin-2-Ones in a One-Pot De-Constructive Approach of Trihalohydrines with 1,2-Diamines”, Chimica sotto l’Albero 2025 – Building peace through chemical bonds”, 18–19 December 2025 Bari (Italy). (PC)
9. De Santis, G. Colella, M.; Spennacchio, M.; Andresini, M.; Luisi, R.; Degennaro, L. “Synthesis of fluoroamides, acylfluorides, and aminoamides through a divergent self-deoxyfluorination of bromodifluoromethyl alcohols under batch and mechanochemical conditions”, Chimica sotto l’Albero 2024 – Innovation for a Green, Healthy, and Digital World, 19–20 December 2024, Bari (Italy). (OC)
10. Gnavi, R.; De Nardi, F.; Meazzo, C.; Maranzana, A.; Prandi, C.; Blangetti, M. “Oxidative anionic homo-Fries rearrangement under bench-type aerobic conditions”. XXVIII Congresso Nazionale della Società Chimica Italiana (SCI 2024), 26–30 August 2024, Milano (Italy). (OC)
11. Marra, F.; Coldham, I.; Blangetti, M. “Organolithium-induced Kinetic Resolution and Anionic Fries Rearrangement of O-Aryl Carbamates.” XXVIII Congresso Nazionale della Società Chimica Italiana (SCI 2024), 26–30 August 2024, Milano (Italy). (OC)
12. Meazzo, C.; De Nardi, F.; Lauria, F.; Ghinato, S.; Maranzana, A.; Prandi, C.; Blangetti, M. “Theoretical study of the reaction mechanism and solvent effect in the reaction between LiCH₂SiMe and N-benzoylpirrolydine”, XXVIII Congresso Nazionale della Società Chimica Italiana (SCI 2024), 26–30 August 2024, Milano (Italy). (PC)
13. Blangetti, M.; Gnavi, R.; De Nardi, F.; Meazzo, C.; Grimaldi, E.; Maranzana, A.; Prandi, C. “Oxidative Anionic homo-Fries Rearrangement Under Bench-Type Aerobic Conditions”, 9th EuChemS Chemistry Congress (ECC-9), 7–11 July 2024, Dublin (Ireland). (OC)

Gruppi di ricerca

• SMCO - Sintesi
• SMCO - Sintesi e meccanismi

Attività in agenda

Consulta la mia agenda

Organi

• Commissione Didattica
• Consiglio di Dipartimento

• Consiglio Integrato dei Corsi di Studio in Scienze e Tecnologie Alimentari

Ricevimento studenti

Avvisi

Laboratorio di Sintesi Organiche (CHI0124): turni PROVVISORI a.a. 2025/2026

 

Gentili studenti/esse,

alleghiamo al presente avviso i turni PROVVISORI del Laboratorio di Sintesi Organiche (III anno, curriculum Chimica) per l'a.a. 2025/2026, comprendenti tutti gli studenti che hanno correttamente compilato il Google Form entro il 31/07/2025 e che hanno regolarmente superato gli esami di propedeuticità entro la stessa data.

E’ possibile effettuare scambi alla pari tra i tre turni a cura degli studenti. Vi preghiamo di comunicare al Prof. Blangetti (marco.blangetti@unito.it) tali scambi debitamente motivati entro e non oltre le ore 18.00 del 26/09/2025.

Chi erroneamente non dovesse comparire nell'elenco dei turni, pur avendo compilato correttamente il GForm entro il 31/07 e in regola con gli esami di propedeuticità al 31/07, è pregato di contattare tempestivamente il Prof. Blangetti (marco.blangetti@unito.it) entro e non oltre le ore 18.00 del giorno 12/09/2025 allegando ricevuta del superamento degli esami di sbarramento.

Il laboratorio si svolgerà secondo il seguente calendario:

- turno 1: dal 13 ottobre al 30 ottobre

- turno 2: dal 04 novembre al 14 novembre

- turno 3: dal 11 dicembre al 19 dicembre

salvo eventuali modifiche di orario che verranno comunicate tempestivamente.

I docenti del corso

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{{[Laboratorio di Sintesi Organiche (CHI0124): turni PROVVISORI a.a. 2025/2026]}}